Fatty acid desaturase 1 drives esophageal cancer via M1 macrophage ferroptosis and lipid metabolism remodeling

doi:10.4251/wjgo.124110

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World Journal of Gastrointestinal Oncology

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1948-5204

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Nov 15, 2026; 18(11): 124110
Published online Nov 15, 2026. doi: 10.4251/wjgo.124110

Table 2 Key mediator metabolites identified in the fatty acid desaturase 1-mediated metabolic pathway analysis

Metabolite	β₁	β₂	Mediation effect (β₁ × β₂)	Mediation proportion	P value
1-linoleoyl-GPE (18:2)	0.446	-0.285	-0.127	45.12%	0.006385603
1,2-dilinoleoyl-GPC (18:2/18:2)	0.451	-0.280	-0.126	44.84%	0.006059174
1-palmitoyl-2-stearoyl-gpc (16:0/18:0)	-0.399	0.449	-0.179	63.64%	0.006666497
1-stearoyl-2-arachidonoyl-GPE (18:0/20:4)	-0.392	0.294	-0.116	41.04%	0.000979761
1-linoleoyl-2-arachidonoyl-GPC (18:2/20:4n-6)	-0.559	0.240	-0.134	47.61%	0.000806059

β₁: Effect of fatty acid desaturase 1 on metabolite (inverse variance weighted); β₂: Effect of metabolite on esophageal cancer risk (inverse variance weighted); mediation effect = β₁ × β₂; mediation proportion = (mediation effect/total effect) × 100%; P value from the delta method (two-sided); GPE: Glycerophosphoethanolamine; GPC: Glycerophosphocholine.

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Citation: Du QC, Bai Y, Zhou DH, Yu H, Nian H. Fatty acid desaturase 1 drives esophageal cancer via M1 macrophage ferroptosis and lipid metabolism remodeling. World J Gastrointest Oncol 2026; 18(11): 124110
URL: https://www.wjgnet.com/1948-5204/full/v18/i11/124110.htm
DOI: https://dx.doi.org/10.4251/wjgo.124110

Du QC, Bai Y, Zhou DH, Yu H, Nian H. Fatty acid desaturase 1 drives esophageal cancer via M1 macrophage ferroptosis and lipid metabolism remodeling. World J Gastrointest Oncol 2026; 18(11): 124110 [DOI: 10.4251/wjgo.124110]

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