Fatty acid desaturase 1 drives esophageal cancer via M1 macrophage ferroptosis and lipid metabolism remodeling

doi:10.4251/wjgo.124110

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 18, Issue 11

This Article

(10)

(11)

(0)

(645)

Peer-Review Report of This Article

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Oncology

ISSN

1948-5204

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Nov 15, 2026; 18(11): 124110
Published online Nov 15, 2026. doi: 10.4251/wjgo.124110

Table 1 Mendelian randomization estimates for the causal associations of five ferroptosis-related genes with esophageal cancer risk using the inverse variance weighted method

ID	NSNP	Method	β	SE	OR	OR_lci95	OR_uci95	P value
FADS2	14	IVW	-0.172	0.051	0.842	0.763	0.930	0.0007
FADS1	9	IVW	-0.282	0.097	0.755	0.624	0.913	0.0038
SRC	3	IVW	-2.202	0.951	0.111	0.017	0.713	0.0206
ELOVL5	3	IVW	0.492	0.237	1.635	1.027	2.603	0.0384
PPARG	7	IVW	-0.470	0.234	0.625	0.395	0.989	0.0445

FADS2: Fatty acid desaturase 2; FADS1: Fatty acid desaturase 1; SRC: SRC proto-oncogene, non-receptor tyrosine kinase; ELOVL5: Elongation of very long chain fatty acids protein 5; PPARG: Peroxisome proliferator-activated receptor gamma; IVW: Inverse variance weighted; NSNP: Number of single nucleotide polymorphisms; OR_lci95: Odds ratio lower 95% confidence interval; OR_uci95: Odds ratio upper 95% confidence interval.

Full Size Table

Citation: Du QC, Bai Y, Zhou DH, Yu H, Nian H. Fatty acid desaturase 1 drives esophageal cancer via M1 macrophage ferroptosis and lipid metabolism remodeling. World J Gastrointest Oncol 2026; 18(11): 124110
URL: https://www.wjgnet.com/1948-5204/full/v18/i11/124110.htm
DOI: https://dx.doi.org/10.4251/wjgo.124110

Du QC, Bai Y, Zhou DH, Yu H, Nian H. Fatty acid desaturase 1 drives esophageal cancer via M1 macrophage ferroptosis and lipid metabolism remodeling. World J Gastrointest Oncol 2026; 18(11): 124110 [DOI: 10.4251/wjgo.124110]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.