Ferroptosis-mitochondria-related molecular subtypes and prognostic signature reveal immune and pathway heterogeneity in hepatocellular carcinoma

Figure 4 Construction and internal validation of the six-gene ferroptosis-mitochondria-related prognostic signature. A: Least absolute shrinkage and selection operator coefficient profiles; B: Tenfold cross-validation curve for selection of the optimal penalty parameter; C: Risk score distribution in the full The Cancer Genome Atlas liver hepatocellular carcinoma (TCGA-LIHC) cohort; D: Survival status distribution in the full cohort; E: Heatmap of the six model genes ordered by risk score; F: Kaplan-Meier overall survival curves for the full TCGA-LIHC high- and low-risk groups; G: Time-dependent receiver operating characteristic curves for 1-, 3-, and 5-year overall survival in the full TCGA-LIHC cohort; H: Kaplan-Meier curves for the training cohort (n = 256; log-rank P = 3.66 × 10^-6); I: Time-dependent receiver operating characteristic curves in the training cohort, with 1-, 3-, and 5-year areas under the curve of 0.792, 0.730, and 0.721, respectively; J: Kaplan-Meier curves for the internal validation cohort (n = 110; log-rank P = 0.0245); K: Time-dependent receiver operating characteristic curves in the internal validation cohort, with 1-, 3-, and 5-year areas under the curve of 0.767, 0.740, and 0.575, respectively. TCGA-LIHC: The Cancer Genome Atlas liver hepatocellular carcinoma; AUC: Area under the curve; ROC: Receiver operating characteristic.