Ferroptosis-mitochondria-related molecular subtypes and prognostic signature reveal immune and pathway heterogeneity in hepatocellular carcinoma

doi:10.4251/wjgo.124061

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Nov 15, 2026; 18(11): 124061
Published online Nov 15, 2026. doi: 10.4251/wjgo.124061

Table 1 External validation performance summary of the six-gene risk score

Dataset	n	HR	95%CI	Cox P value	KM log-rank P	1-year AUC	3-year AUC	5-year AUC
GSE14520	221	1.60	1.01-2.54	0.047	0.158	0.623	0.567	0.508
ICGC-LIRI-JP	93	2.58	1.15-5.80	0.022	0.327	0.682	0.648	0.581

Hazard ratios were derived from univariate Cox regression using the continuous risk score. The dichotomized Kaplan-Meier analysis was used only to visualize risk-group separation. AUC: Area under the curve; CI: Confidence interval; HR: Hazard ratio; KM: Kaplan-Meier; ICGC-LIRI-JP: International Cancer Genome Consortium Liver Cancer-RIKEN Japan.

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Citation: Han S, Feng ZW, Ran Y, Ma GP, Zhou YC, Lv JZ, Li XB, Wang CH, Wang LZ, Hu SP. Ferroptosis-mitochondria-related molecular subtypes and prognostic signature reveal immune and pathway heterogeneity in hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(11): 124061
URL: https://www.wjgnet.com/1948-5204/full/v18/i11/124061.htm
DOI: https://dx.doi.org/10.4251/wjgo.124061

Han S, Feng ZW, Ran Y, Ma GP, Zhou YC, Lv JZ, Li XB, Wang CH, Wang LZ, Hu SP. Ferroptosis-mitochondria-related molecular subtypes and prognostic signature reveal immune and pathway heterogeneity in hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(11): 124061 [DOI: 10.4251/wjgo.124061]

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