Prognostic impact of post-chemoradiotherapy muscle quality in non-elderly adults with esophageal squamous cell carcinoma

Table 2 Univariate and multivariate Cox regression analyses of factors associated with overall survival

Characteristics	Total (n)	Univariate analysis		Multivariate analysis
		HR (95%CI)	P value	HR (95%CI)	P value
Sex	255
Female	55	Reference
Male	200	1.037 (0.714-1.507)	0.849
Age	255	1.012 (0.993-1.030)	0.217
KPS	255
70	6	Reference		Reference
80	107	0.483 (0.210-1.110)	0.086	0.632 (0.266-1.504)	0.300
90	140	0.380 (0.166-0.872)	0.022	0.522 (0.220-1.234)	0.138
100	2	0.966 (0.195-4.795)	0.966	1.167 (0.224-6.064)	0.855
Smoking history	255
No	108	Reference
Yes	147	1.161 (0.851-1.585)	0.346
Alcohol history	255
No	115	Reference		Reference
Yes	140	1.335 (0.979-1.821)	0.068	1.475 (1.073-2.026)	0.017
Tumor location	255
Cervical	8	Reference
Upper thoracic	53	2.242 (0.686-7.327)	0.181
Middle thoracic	96	2.234 (0.701-7.118)	0.174
Lower thoracic	86	2.144 (0.670-6.860)	0.199
Abdominal	12	2.300 (0.622-8.505)	0.212
TNM	255
I-III	138	Reference
IV	117	1.036 (0.762-1.408)	0.822
Chemotherapy cycle	255	0.927 (0.822-1.044)	0.211
RT dose	255	1.012 (0.983-1.042)	0.405
Post-TC	255	0.786 (0.675-0.914)	0.002	0.840 (0.716-0.985)	0.032
Post-TG	255	0.616 (0.465-0.815)	< 0.001	0.707 (0.526-0.949)	0.021
Post-BMI	255	0.918 (0.864-0.976)	0.006	0.925 (0.866-0.989)	0.022
Post-Hb	255	0.998 (0.988-1.007)	0.636
Post-Alb	255	0.992 (0.969-1.016)	0.524
Post-PNI	255	1.002 (0.988-1.017)	0.747
Post-NLR	255	1.004 (0.992-1.017)	0.485
Post-LMM	254
No	66	Reference
Yes	188	0.767 (0.547-1.076)	0.125
Post-SMD	255
Low group	155	Reference		Reference
High group	100	0.709 (0.516-0.976)	0.035	0.654 (0.473-0.905)	0.010

HR: Hazard ratio; 95%CI: 95% confidence interval; KPS: Karnofsky Performance Status; RT: Radiotherapy; Post-TC: Post-treatment total cholesterol; Post-TG: Post-treatment triglyceride; Post-BMI: Post-treatment body mass index; Post-Hb: Post-treatment hemoglobin; Post-Alb: Post-treatment albumin; Post-PNI: Post-treatment Prognostic Nutritional Index; Post-NLR: Post-treatment neutrophil-to-lymphocyte ratio; Post-LMM: Post-treatment low muscle mass; Post-SMD: Post-treatment skeletal muscle density.