Microbial succession driven by Alistipes depletion shapes the mesenchymal and immune-excluded consensus molecular subtype 4 colorectal cancer landscape

Figure 6 Microbial features and functional pathways associated with Consensus Molecular Subtypes 4 subtype. A: Sankey diagram visualizing Kyoto Encyclopedia of Genes and Genomes orthology-pathway-function connections showing modules enriched in Alistipes indistinctus; B: Species-level differences between tumor and adjacent tissue (cancer tissue vs cancer-adjacent para-carcinoma) highlighting the top species with the largest mean abundance shifts; C: Mean relative abundances of the top 20 species identified in Consensus Molecular Subtypes 4 samples; D: Heatmap showing sample-level abundance (log₁₀-transformed) of the top 20 species in Consensus Molecular Subtypes 4 fecal samples; E: Heatmap illustrating Alistipes indistinctus proteins mapped to colorectal cancer-related Kyoto Encyclopedia of Genes and Genomes pathways. CMS: Consensus Molecular Subtypes; CRC: Colorectal cancer; KEGG: Kyoto Encyclopedia of Genes and Genomes.