Microbial succession driven by Alistipes depletion shapes the mesenchymal and immune-excluded consensus molecular subtype 4 colorectal cancer landscape

Figure 5 Microbiome diversity, composition, and host-microbe associations across Consensus Molecular Subtypes classifications. A: Stacked bar plots showing the relative abundance of dominant microbial taxa across Consensus Molecular Subtypes (CMS) classifications and sample types; B: Heatmap illustrating correlations between selected host genes and microbial phyla in cancer tissue, cancer-adjacent para-carcinoma, and F samples; C: Mean relative abundances of the top 20 differential species across CMS1-CMS4; D: Species-level differences (cancer tissue vs cancer-adjacent para-carcinoma) showing top 20 species with the largest mean abundance shifts per CMS classification; E: Shannon diversity indices comparing α-diversity of tumor (cancer tissue), adjacent (cancer-adjacent para-carcinoma), and fecal (F) microbiomes by CMS classification. CA: Cancer tissue; CP: Cancer-adjacent para-carcinoma; CMS: Consensus Molecular Subtypes.