Microbial succession driven by Alistipes depletion shapes the mesenchymal and immune-excluded consensus molecular subtype 4 colorectal cancer landscape

doi:10.4251/wjgo.122507

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 18, Issue 11

This Article

(7)

(10)

(0)

(164)

Peer-Review Report of This Article

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Oncology

ISSN

1948-5204

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Nov 15, 2026; 18(11): 122507
Published online Nov 15, 2026. doi: 10.4251/wjgo.122507

Full Size Figure Download Figure

Figure 1 Workflow of the study. Tumor, adjacent tissue, and fecal samples from 11 patients with colorectal cancer were analyzed. Gene expression profiles were compared with The Cancer Genome Atlas data and Consensus Molecular Subtypes (CMS) templates by principal component analysis, and classified by CMS using CMSclassifier. Differential expression, immune infiltration, and microbiome features were examined across subtypes, with host-microbiota associations further explored to identify CMS4-specific microbial signals. CMS: Consensus Molecular Subtypes.

Citation: Hu JD, Qiu CJ, Song ZB, Xia ZW, Wang HT, Geng H. Microbial succession driven by Alistipes depletion shapes the mesenchymal and immune-excluded consensus molecular subtype 4 colorectal cancer landscape. World J Gastrointest Oncol 2026; 18(11): 122507
URL: https://www.wjgnet.com/1948-5204/full/v18/i11/122507.htm
DOI: https://dx.doi.org/10.4251/wjgo.122507

Hu JD, Qiu CJ, Song ZB, Xia ZW, Wang HT, Geng H. Microbial succession driven by Alistipes depletion shapes the mesenchymal and immune-excluded consensus molecular subtype 4 colorectal cancer landscape. World J Gastrointest Oncol 2026; 18(11): 122507 [DOI: 10.4251/wjgo.122507]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.