HMGA2 promotes epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma via transforming growth factor-β/small mothers against decapentaplegic 2

doi:10.4251/wjgo.121485

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World Journal of Gastrointestinal Oncology

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1948-5204

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Nov 15, 2026; 18(11): 121485
Published online Nov 15, 2026. doi: 10.4251/wjgo.121485

Table 3 Multivariate analyses of overall survival in intrahepatic cholangiocarcinoma patients

Variables	Factors	β	SE	Wald	P value	HR (95%CI)
Differentiation degree	Well, moderately/poorly	0.610	0.349	3.045	0.081	1.840 (0.928-3.650)
Surgical margin	Negative/positive	0.416	0.588	0.501	0.479	1.516 (0.479-4.800)
Vascular invasion	No/yes	0.713	0.323	4.869	0.027	2.040 (1.083-3.844)
HMGA2	Negative/positive	0.820	0.342	5.769	0.016	2.271 (1.163-4.437)

HR: Hazard ratio; CI: Confidence interval.

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Citation: Zhang YN, Hao JY, Lei X, Wang PF, Xu SC, Huang XJ. HMGA2 promotes epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma via transforming growth factor-β/small mothers against decapentaplegic 2. World J Gastrointest Oncol 2026; 18(11): 121485
URL: https://www.wjgnet.com/1948-5204/full/v18/i11/121485.htm
DOI: https://dx.doi.org/10.4251/wjgo.121485

Zhang YN, Hao JY, Lei X, Wang PF, Xu SC, Huang XJ. HMGA2 promotes epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma via transforming growth factor-β/small mothers against decapentaplegic 2. World J Gastrointest Oncol 2026; 18(11): 121485 [DOI: 10.4251/wjgo.121485]

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