Angelica sinensis polysaccharide attenuates constipation-associated colorectal carcinogenesis by inhibiting the NLRP3/Caspase-1/IL-1β inflammasome axis

Figure 7 Angelica sinensis polysaccharide suppresses inflammatory mediator mRNA expression via the NOD-like receptor protein 3/caspase-1/ interleukin-1β pathway. A: IL-1β; B: IL-18; C: TNF-α; D: IL-6; E: COX-2; F: MMP-9. Reverse-transcription PCR analysis of interleukin (IL)-1β, IL-18, tumor necrosis factor-alpha, IL-6, COX-2, and matrix metalloproteinase-9 mRNA expression in control, deoxycholic acid, deoxycholic acid + Angelica sinensis polysaccharide (ASP), ASP + nigericin, ASP + nigericin + cycplase 09, and ASP + nigericin + VX-765 groups. ^aP < 0.05. DCA: Deoxycholic acid; ASP: Angelica sinensis polysaccharide; CON: Control; CY-09: Cycplase 09; TNF-α: Tumor necrosis factor-alpha; MMP-9: Matrix metalloproteinase-9; IL: Interleukin; COX-2: Cyclooxygenase-2.