Angelica sinensis polysaccharide attenuates constipation-associated colorectal carcinogenesis by inhibiting the NLRP3/Caspase-1/IL-1β inflammasome axis

Figure 3 Angelica sinensis polysaccharide dose-dependently inhibits caspase-1 activation in deoxycholic acid-stimulated NCM460 cells. A: Representative immunofluorescence images showing CK20 (green), cleaved caspase-1 p20 (red), DAPI (blue), and merged images; B: Quantification of cleaved caspase-1 relative fluorescence intensity. ^aP < 0.05. OC: Culture in vehicle adding equimolar sodium chloride to control for osmolality; DCA: Deoxycholic acid; ASP: Angelica sinensis polysaccharide; CA19-9: Carbohydrate antigen 19-9.