Primary squamous cell carcinoma arising in the liver: A case report and review of literature

Figure 2 Histopathological and immunohistochemical features of the liver biopsy specimen. All hematoxylin and eosin (H&E) and immunohistochemical panels were obtained from the same biopsy specimen. A: H&E staining shows abundant tumor cells (original magnification, × 200); B: Immunohistochemistry shows diffuse nuclear positivity for p63 (original magnification, × 400); C: Nuclear positivity for p40 (original magnification, × 400); D: Cytoplasmic positivity for cytokeratin 5/6 (CK5/6; original magnification, × 400). The combined expression of p63, p40, and CK5/6 supports squamous differentiation of the tumor.