Copyright: ©Author(s) 2026.
World J Gastrointest Oncol. Oct 15, 2026; 18(10): 123966
Published online Oct 15, 2026. doi: 10.4251/wjgo.123966
Published online Oct 15, 2026. doi: 10.4251/wjgo.123966
Table 9 Top 20 highly coupled documents based on comprehensive indicators
| Ref. | Journal | Title | Year | Citations | Total link strength | Cluster | Research theme |
| Tiwari et al[68] | Journal of Biomedical Science | Tumor Microenvironment: Barrier or Opportunity towards Effective Cancer Therapy | 2022 | 290 | 427 | 1 | Tumor microenvironment; Organoids |
| Chen et al[71] | Cancer Cell | Oncogenic Collagen i Homotrimers from Cancer Cells Bind to α3β1 Integrin and Impact Tumor Microbiome and Immunity to Promote Pancreatic Cancer | 2022 | 216 | 188 | 2 | Mechanisms of resistance in pancreatic cancer |
| Mahadevan et al[60] | Cancer Cell | KRAS G12D Inhibition Reprograms the Microenvironment of Early and Advanced Pancreatic Cancer to Promote Fas-mediated Killing by CD8+ T Cells | 2023 | 182 | 432 | 2 | Mechanisms of resistance in pancreatic cancer |
| Dilly et al[72] | Cancer Discovery | Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer | 2024 | 177 | 506 | 2 | Mechanisms of resistance in pancreatic cancer |
| Mucciolo et al[62] | Cancer Cell | EGFR-activated Myofibroblasts Promote Metastasis of Pancreatic Cancer | 2024 | 156 | 476 | 1 | Tumor microenvironment; Organoids |
| Schuth et al[58] | Journal of Experimental & Clinical Cancer Research | Patient-specific Modeling of Stroma-mediated Chemoresistance of Pancreatic Cancer Using A Three-dimensional Organoid-fibroblast Co-culture System | 2022 | 131 | 643 | 6 | Pancreatic cancer organoids |
| Magré et al[73] | Journal for Immunotherapy of Cancer | Emerging Organoid-immune Co-culture Models for Cancer Research: From Oncoimmunology to Personalized Immunotherapies | 2023 | 131 | 362 | 1 | Tumor microenvironment; Organoids |
| Goodwin et al[74] | Cancer Research | Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-mutant Pancreatic Cancer | 2023 | 125 | 195 | 2 | Mechanisms of resistance in pancreatic cancer |
| Proietto et al[65] | Frontiers in Oncology | Tumor Heterogeneity: Preclinical Models, Emerging Technologies, and Future Applications | 2023 | 121 | 438 | 1 | Tumor microenvironment; organoids |
| Haque et al[75] | Microsystems & Nanoengineering | Patient-derived Pancreatic Cancer-on-a-chip Recapitulates the Tumor Microenvironment | 2022 | 113 | 260 | 1 | Tumor microenvironment; organoids |
| Su et al[67] | Science Translational Medicine | Targeting SRC Reactivates Pyroptosis to Reverse Chemoresistance in Lung and Pancreatic Cancer Models | 2023 | 113 | 14 | 1 | Tumor microenvironment; organoids |
| Müller et al[63] | Cell Death and Differentiation | Elevated FSP1 Protects KRAS-mutated Cells from Ferroptosis during Tumor Initiation | 2023 | 108 | 206 | 2 | Mechanisms of resistance in pancreatic cancer |
| Schwörer et al[66] | Cancer Research | Hypoxia Potentiates the Inflammatory Fibroblast Phenotype Promoted by Pancreatic Cancer Cell-derived Cytokines | 2023 | 107 | 318 | 1 | Tumor microenvironment; organoids |
| Grossman et al[59] | Clinical Cancer Research | Organoid Sensitivity Correlates with Therapeutic Response in Patients with Pancreatic Cancer | 2022 | 104 | 614 | 3 | Molecular mechanisms of pancreatic cancer |
| Matthews et al[61] | Plos Computational Biology | Organoid: A Versatile Deep learning Platform for Tracking and Analysis of Single-organoid Dynamics | 2022 | 102 | 45 | 1 | Tumor microenvironment; organoids |
| Braxton et al[76] | Nature | 3D Genomic Mapping Reveals Multifocality of Human Pancreatic Precancers | 2024 | 97 | 111 | 3 | Molecular mechanisms of pancreatic cancer |
| Suarez-Martinez et al[6] | Cell and Bioscience | 3D and Organoid Culture in Research: Physiology, Hereditary Genetic Diseases and Cancer | 2022 | 96 | 569 | 1 | Tumor microenvironment; organoids |
| Wehrli et al[70] | Clinical Cancer Research | Mesothelin CAR T Cells Secreting Anti-fap/anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and Its Stroma | 2024 | 94 | 392 | 1 | Tumor microenvironment; organoids |
| Nelson et al[64] | Nature Communications | USP25 Promotes Pathological HIF-1-driven Metabolic Reprogramming and Is A Potential Therapeutic Target in Pancreatic Cancer | 2022 | 94 | 387 | 3 | Molecular mechanisms of pancreatic cancer |
| Wang et al[69] | Cancer Research | Mitochondrial Calcium Uniporter Drives Metastasis and Confers A Targetable Cystine Dependency in Pancreatic Cancer | 2022 | 90 | 109 | 2 | Mechanisms of resistance in pancreatic cancer |
- Citation: Chen QZ, Chi X, Pan JH, Cheng QZ, Guo YJ, Liu YX, Yu L, Feng WK. Integrating traditional Chinese medicine with pancreatic cancer organoids: Bibliometric insights and translational perspectives. World J Gastrointest Oncol 2026; 18(10): 123966
- URL: https://www.wjgnet.com/1948-5204/full/v18/i10/123966.htm
- DOI: https://dx.doi.org/10.4251/wjgo.123966