Primary colonic malignant peripheral nerve sheath tumor with biphasic morphology: A case report

Table 3 Histologic features and immunohistochemical findings of reported colonic malignant peripheral nerve sheath tumor

Ref.	Histologic features	Immunohistochemical findings
Present case	The tumor showed a biphasic morphology composed of spindle cells arranged in fascicles and small round cells distributed diffusely, set in a vascular-rich stroma with extensive myxoid change	S-100 (+); AE1/AE3 (-); SMA (-); Desmin (-); GFAP (-); NKX2.2 (-); FLI1 (-); SOX10 (-); CD117 (-); CD34 positive only in vascular structures; complete loss of H3K27me3; Ki-67 approximately 90%
Rawal et al[4]	Predominantly composed of spindle cell fascicles	S-100 (+); CD117 (-); DOG1 (-); CD34 (-)
Cyriac et al[5]	Composed of spindle cells and epithelioid cells	S-100 (+); Vimentin (+); HMB45 (-); CD117 (-); DOG1 (-)
Lee et al[6]	Predominantly composed of spindle cell fascicles	S-100 (+); Vimentin (+); AE1/AE3 (-); Desmin (-); Myosin (-); Ki-67 5%-10%
Marwah et al[7]	Predominantly composed of spindle cell fascicles	S-100 (+); CD117 (-); NSE (-); Ki-67 approximately 20%
Al-Shehari et al[8]	Predominantly composed of spindle cell fascicles	S-100 (+); SOX10 (+); CD117 (-); CD34 (-); DOG1 (-); SMA (-); Ki-67 10%
Lakkasani et al[9]	Composed of spindle cell fascicles and pleomorphic cells, with focal rhabdomyoblastic differentiation	S-100 (+); Ki-67 approximately 70%