Metabolic and inflammatory indices in colorectal adenoma: A real-world colonoscopy cohort study

Table 4 Receiver operating characteristic analysis of metabolic and inflammatory markers for adenoma detection

Variable	AUC	95%CI	P value	Optimal cut-off (Youden)	Sensitivity (%)	Specificity (%)
TyG index	0.714	0.684-0.744	< 0.001	8.648	81.0	55.0
Glucose (mg/dL)	0.696	0.666-0.726	< 0.001	97.5	65.5	68.0
Triglycerides (mg/dL)	0.671	0.640-0.702	< 0.001	142.5	63.0	64.2
AIP	0.664	0.633-0.695	< 0.001	0.496	60.7	69.0
HDL cholesterol (mg/dL)	0.414	0.384-0.445	< 0.001	44.5	62.0	41.8
Neutrophils (103/μL)	0.560	0.529-0.591	0.001	4.65	58.0	54.0
NHR	0.593	0.562-0.624	< 0.001	0.087	61.5	56.0
NLR	0.517	0.486-0.548	0.266	-	-	-
PLR	0.522	0.491-0.553	0.177	-	-	-
SII	0.508	0.477-0.539	0.594	-	-	-

Receiver operating characteristic analyses were performed to evaluate the ability of each marker to discriminate adenoma presence. Optimal cut-off values were determined using the Youden index. Analyses were performed using complete-case data for each parameter because laboratory availability varied across patients in this retrospective cohort. Cut-off values were not calculated for parameters without statistically significant receiver operating characteristic discrimination. Because high-density lipoprotein cholesterol was inversely associated with colorectal adenoma, an area under the curve below 0.50 reflects the direction of this association rather than poor discriminatory performance. AUC: Area under the curve; TyG: Triglyceride-glucose; AIP: Atherogenic index of plasma; HDL: High-density lipoprotein; NHR: Neutrophil-to-high-density lipoprotein ratio; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; SII: Systemic immune-inflammation index.