Mechanisms of the gut-lung axis in regulating lung metastasis of colorectal cancer and advances in traditional Chinese medicine intervention

doi:10.4251/wjgo.123494

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Oct 15, 2026; 18(10): 123494
Published online Oct 15, 2026. doi: 10.4251/wjgo.123494

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Figure 4 Traditional Chinese medicine interventions that target the gut-lung axis. The diagram shows a summary of how traditional Chinese medicine formulas (Si-Jun-Zi decoction, Hedyotis diffusa-Scutellaria barbata) and active compounds (baicalin, berberine, astragalus polysaccharides) recover gut microbial diversity, repair the intestinal barrier, reduce exosomal release of pro-metastatic factors, and adjust immune cell movement, hence hindering lung metastasis. ETBF: Enterotoxigenic Bacteroides fragilis; ZO-1: Zonula occludens-1; miRNAs: MicroRNAs; circRNAs: Circular RNAs; Th17: T helper 17; Treg: Regulatory T.

Citation: Wang GL, Deng H, Wang G, Qu NN. Mechanisms of the gut-lung axis in regulating lung metastasis of colorectal cancer and advances in traditional Chinese medicine intervention. World J Gastrointest Oncol 2026; 18(10): 123494
URL: https://www.wjgnet.com/1948-5204/full/v18/i10/123494.htm
DOI: https://dx.doi.org/10.4251/wjgo.123494

Wang GL, Deng H, Wang G, Qu NN. Mechanisms of the gut-lung axis in regulating lung metastasis of colorectal cancer and advances in traditional Chinese medicine intervention. World J Gastrointest Oncol 2026; 18(10): 123494 [DOI: 10.4251/wjgo.123494]

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