Prognostic value of the prognostic immune-inflammatory-nutritional score in patients with advanced gastric cancer treated with immunochemotherapy

Table 6 Comparison of adverse events stratified by prognostic immune-inflammatory-nutritional score (< 25.69 vs ≥ 25.69) in patients, n (%)

Variables	Total (n = 200)	Low (n = 68)	High (n = 132)	χ2	P value
Leukopenia	82 (41.00)	30 (44.12)	52 (39.39)	0.41	0.520
Anemia	88 (44.00)	32 (47.06)	56 (42.42)	0.39	0.532
Neutropenia	85 (42.50)	35 (51.47)	50 (37.88)	3.39	0.065
Thrombocytopenia	66 (33.00)	27 (39.71)	39 (29.55)	2.10	0.148
Nausea	54 (27.00)	22 (32.35)	32 (24.24)	1.50	0.221
Pyrexia	54 (27.00)	24 (35.29)	30 (22.73)	3.60	0.058
Elevated ALT	31 (15.50)	15 (22.06)	16 (12.12)	3.38	0.066
Elevated AST	38 (19.00)	18 (26.47)	20 (15.15)	3.74	0.053
Hypothyroidism	34 (17.00)	16 (23.53)	18 (13.64)	3.11	0.078
Hypertension	28 (14.00)	10 (14.71)	18 (13.64)	0.04	0.836
Pneumonitis	23 (11.50)	9 (13.24)	14 (10.61)	0.30	0.581
Hyperbilirubinemia	17 (8.50)	6 (8.82)	11 (8.33)	0.01	0.906
Fatigue	31 (15.50)	13 (19.12)	18 (13.64)	1.03	0.310
> 3 grades: Leukopenia	20 (10.00)	9 (13.24)	11 (8.33)	1.20	0.274
> 3 grades: Anemia	17 (8.50)	6 (8.82)	11 (8.33)	0.01	0.906
> 3 grades: Neutropenia	26 (13.00)	12 (17.65)	14 (10.61)	1.97	0.161
> 3 grades: Thrombocytopenia	36 (18.00)	16 (23.53)	20 (15.15)	2.13	0.144
> 3 grades: Nausea	9 (4.50)	4 (5.88)	5 (3.79)	0.10	0.751
> 3 grades: Elevated ALT	7 (3.50)	4 (5.88)	3 (2.27)	0.83	0.363
> 3 grades: Elevated AST	9 (4.50)	3 (4.41)	6 (4.55)	0.00	1.000
> 3 grades: Hypothyroidism	6 (3.00)	3 (4.41)	3 (2.27)	0.16	0.687
> 3 grades: Hypertension	8 (4.00)	3 (4.41)	5 (3.79)	0.00	1.000
> 3 grades: Pneumonitis	3 (1.50)	1 (1.47)	2 (1.52)	0.00	1.000
> 3 grades: Hyperbilirubinemia	6 (3.00)	2 (2.94)	4 (3.03)	0.00	1.000

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.