Prognostic value of the prognostic immune-inflammatory-nutritional score in patients with advanced gastric cancer treated with immunochemotherapy

Table 1 Baseline characteristics stratified by prognostic immune-inflammatory-nutritional score (< 25.69 vs ≥ 25.69), mean ± SD/n (%)

Variables	Total (n = 200)	Low (n = 68)	High (n = 132)	t /χ2	P value
ALBI	-2.38 ± 0.54	-2.48 ± 0.49	-2.33 ± 0.56	-1.88	0.061
NLR	3.21 ± 2.01	2.01 ± 0.91	3.83 ± 2.14	-8.38	< 0.001
SII	748.17 ± 528.33	433.34 ± 234.34	910.35 ± 563.89	-8.41	< 0.001
PNI	42.49 ± 6.61	44.21 ± 5.64	41.61 ± 6.92	2.68	0.008
FIB	2.85 ± 0.82	2.36 ± 0.46	3.10 ± 0.86	-7.89	< 0.001
Gender				0.21	0.644
Female	75 (37.50)	24 (35.29)	51 (38.64)
Male	125 (62.50)	44 (64.71)	81 (61.36)
Age (years)				0.06	0.801
< 60 years	78 (39.00)	28 (41.18)	50 (37.88)
≥ 60 years	122 (61.00)	40 (58.82)	82 (62.12)
BMI (kg/m2)				3.11	0.078
< 25	166 (83.00)	52 (76.47)	114 (86.36)
≥ 25	34 (17.00)	16 (23.53)	18 (13.64)
CEA (ng/mL)				0.76	0.382
≥ 3	121 (60.50)	44 (64.71)	77 (58.33)
< 3	79 (39.50)	24 (35.29)	55 (41.67)
CA199 (ng/mL)				0.76	0.382
< 37	127 (63.50)	46 (67.65)	81 (61.36)
≥ 37	73 (36.50)	22 (32.35)	51 (38.64)
ECOG				3.34	0.068
0	71 (35.50)	30 (44.12)	41 (31.06)
1	129 (64.50)	38 (55.88)	91 (68.94)
TNM staging				0.14	0.705
III	89 (44.50)	29 (42.65)	60 (45.45)
IV	111 (55.50)	39 (57.35)	72 (54.55)
Differentiation				4.37	0.037
Poorly/undifferentiated	180 (90.00)	57 (83.82)	123 (93.18)
Medium/high	20 (10.00)	11 (16.18)	9 (6.82)
Peritoneal metastasis				3.54	0.060
No	113 (56.50)	45 (66.18)	68 (51.52)
Yes	87 (43.50)	23 (33.82)	64 (48.48)
Liver metastasis				2.82	0.093
No	157 (78.50)	58 (85.29)	99 (75.00)
Yes	43 (21.50)	10 (14.71)	33 (25.00)
PD-L1 expression				3.55	0.060
CPS < 5	95 (47.50)	26 (38.24)	69 (52.27)
CPS ≥ 5	105 (52.50)	42 (61.76)	63 (47.73)
MMR status				0.99	0.319
pMMR	158 (79.00)	51 (75.00)	107 (81.06)
dMMR	42 (21.00)	17 (25.00)	25 (18.94)

ALBI: Albumin-bilirubin; NLR: Neutrophil-to-lymphocyte ratio; SII: Systemic immune-inflammation index; PNI: Prognostic nutritional index; FIB: Fibrinogen; BMI: Body mass index; CEA: Carcinoembryonic-antigen; CA199: Carbohydrate antigen 199; ECOG: Eastern Cooperative Oncology Group; PD-L1: Programmed death-ligand 1; CPS: Combined positive score; MMR: Mismatch repair; pMMR: Proficient mismatch repair; dMMR: Deficient mismatch repair.