Context-dependent prognostic role of neutrophils and mast cells in primary colorectal cancer and liver metastases

Table 3 Hazard ratios for disease-free survival between high vs low densities of CD117+ mast cells in the non-tumor mucosa and per individual regions of interest of primary colorectal cancer and liver metastasis in colorectal cancer patients with synchronous and metachronous metastasis

	Synchronous		Metachronous
	n (%)	HR (95%CI), P value	n (%)	HR (95%CI), P value
NM	40 (74.1)	1.51 (0.74-3.09), 0.26	32 (74.4)	0.85 (0.41-1.77), 0.67
pTC	40 (74.1)	0.69 (0.36-1.33), 0.27	31 (73.8)	2.34 (1.05-5.23), 0.038a
pIM	40 (74.1)	1.04 (0.53-2.04), 0.91	31 (70.5)	0.96 (0.48-1.92), 0.92
pOM	40 (74.1)	0.98 (0.51-1.90), 0.96	31 (73.8)	0.67 (0.32-1.40), 0.28
pIM/pOM	27 (50.0)	1.54 (0.86-2.74), 0.14	21 (50.0)	1.66 (0.86-3.22), 0.13
pPT	40 (74.1)	1.02 (0.53-1.97), 0.95	31 (73.8)	0.86 (0.41-1.80), 0.69
mTC	39 (75.0)	0.69 (0.35-1.34), 0.27	33 (75.0)	1.20 (0.57-2.49), 0.63
mIM	39 (75.0)	0.91 (0.46-1.81), 0.80	32 (74.4)	0.83 (0.40-1.72), 0.62
mOM	40 (75.5)	1.15 (0.57-2.31), 0.71	32 (74.4)	1.61 (0.73-3.58), 0.24
mIM/mOM	27 (50.9)	0.65 (0.36-1.18), 0.16	22 (51.2)	0.93 (0.48-1.78), 0.82
mPT	40 (75.5)	0.74 (0.38-1.43), 0.37	32 (74.4)	1.35 (0.63-2.88), 0.44

^aP < 0.05.

n shows the number of patients in “high” group. HR (95%CI) shows the relative risk compared with 1.00 for the “low” group. NM: Non-tumor mucosa; pTC: Tumor center of primary colorectal cancer; mTC: Tumor center of liver metastasis; pIM: Inner margin of primary colorectal cancer; mIM: Inner margin of liver metastasis; pOM: Outer margin of primary colorectal cancer; mOM: Outer margin of liver metastasis; pPT: Peritumor zone of primary colorectal cancer; mPT: Peritumor zone of liver metastasis.