Context-dependent prognostic role of neutrophils and mast cells in primary colorectal cancer and liver metastases

Table 2 Hazard ratios for disease-free survival between high vs low densities of CD66b+ polymorphonuclear neutrophils in the non-tumor mucosa and per individual regions of interest of primary colorectal cancer and liver metastasis in colorectal cancer patients with synchronous and metachronous metastasis

	Synchronous		Metachronous
	n (%)	HR (95%CI), P value	n (%)	HR (95%CI), P value
NM	40 (74.1)	1.68 (0.85-3.31), 0.13	33 (75.0)	1.56 (0.73-3.35), 0.25
pTC	40 (75.5)	0.65 (0.34-1.24), 0.19	31 (73.8)	0.89 (0.41-1.93), 0.77
pIM	40 (75.5)	0.86 (0.45-1.64), 0.64	31 (73.8)	1.15 (0.54-2.46), 0.71
pOM	39 (75.0)	1.13 (0.57-2.24), 0.72	31 (73.8)	2.59 (1.11-6.02), 0.027a
pIM/pOM	27 (51.9)	0.57 (0.31-1.03), 0.06	21 (50.0)	1.30 (0.67-2.51), 0.44
pPT	39 (75.0)	0.61 (0.31-1.18), 0.14	31 (73.8)	1.92 (0.87-4.25), 0.11
mTC	38 (74.5)	0.95 (0.49-1.85), 0.89	33 (75.0)	0.48 (0.24-0.99), 0.048a
mIM	39 (75.0)	1.70 (0.84-3.46), 0.14	32 (74.4)	0.65 (0.31-1.36), 0.25
mOM	40 (75.5)	2.40 (1.14-5.04), 0.021a	32 (74.4)	0.76 (0.36-1.58), 0.46
mIM/mOM	26 (49.1)	0.89 (0.50-1.59), 0.69	21 (48.8)	1.23 (0.64-2.36), 0.53
mPT	40 (75.5)	2.58 (1.22-5.46), 0.013a	32 (74.4)	0.93 (0.44-1.99), 0.85

^aP < 0.05.

n shows the number of patients in “high” group. HR (95%CI) shows the relative risk compared with 1.00 for the “low” group. NM: Non-tumor mucosa; pTC: Tumor center of primary colorectal cancer; mTC: Tumor center of liver metastasis; pIM: Inner margin of primary colorectal cancer; mIM: Inner margin of liver metastasis; pOM: Outer margin of primary colorectal cancer; mOM: Outer margin of liver metastasis; pPT: Peritumor zone of primary colorectal cancer; mPT: Peritumor zone of liver metastasis.