Context-dependent prognostic role of neutrophils and mast cells in primary colorectal cancer and liver metastases

doi:10.4251/wjgo.122608

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World Journal of Gastrointestinal Oncology

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1948-5204

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Retrospective Cohort Study

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World J Gastrointest Oncol. Oct 15, 2026; 18(10): 122608
Published online Oct 15, 2026. doi: 10.4251/wjgo.122608

Table 1 Correlation between CD66b+ polymorphonuclear neutrophils and CD117+ mast cells densities within non-tumor mucosa, primary colorectal cancer and liver metastasis in synchronous and metachronous groups

	Synchronous						Metachronous
	CD66b NM	CD66b pTC	CD66b pIM	CD66b pOM	CD66b pPT		CD66b NM	CD66b pTC	CD66b pIM	CD66b pOM	CD66b pPT
CD117 NM	0.11¹					CD117 NM	0.08
CD117 pTC		0.13				CD117 pTC		0.08
CD117 pIM			0.07			CD117 pIM			0.01
CD117 pOM				0.32^a		CD117 pOM				0.09
CD117 pPT					0.30^a	CD117 pPT					0.1
		CD66b mTC	CD66b mIM	CD66b mOM	CD66b mPT			CD66b mTC	CD66b mIM	CD66b mOM	CD66b mPT
CD117 mTC		-0.37^a				CD117 mTC		-0.03
CD117 mIM			-0.26			CD117 mIM			0.06
CD117 mOM				-0.13		CD117 mOM				0.15
CD117 mPT					0.06	CD117 mPT					0.12

¹Spearman rho.

^aP < 0.05.

NM: Non-tumor mucosa; pTC: Tumor center of primary colorectal cancer; mTC: Tumor center of liver metastasis; pIM: Inner margin of primary colorectal cancer; mIM: Inner margin of liver metastasis; pOM: Outer margin of primary colorectal cancer; mOM: Outer margin of liver metastasis; pPT: Peritumor zone of primary colorectal cancer; mPT: Peritumor zone of liver metastasis.

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Citation: Ye WJ, Ali E, Pavlov S, Červenková L, Ambrozkiewicz F, Vyčítal O, Hošek P, Daum O, Liška V, Hemminki K, Trailin A. Context-dependent prognostic role of neutrophils and mast cells in primary colorectal cancer and liver metastases. World J Gastrointest Oncol 2026; 18(10): 122608
URL: https://www.wjgnet.com/1948-5204/full/v18/i10/122608.htm
DOI: https://dx.doi.org/10.4251/wjgo.122608

Ye WJ, Ali E, Pavlov S, Červenková L, Ambrozkiewicz F, Vyčítal O, Hošek P, Daum O, Liška V, Hemminki K, Trailin A. Context-dependent prognostic role of neutrophils and mast cells in primary colorectal cancer and liver metastases. World J Gastrointest Oncol 2026; 18(10): 122608 [DOI: 10.4251/wjgo.122608]

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