Association between gut microbial dysbiosis and clinical prognosis of advanced colorectal cancer

doi:10.4251/wjgo.122497

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World Journal of Gastrointestinal Oncology

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1948-5204

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World J Gastrointest Oncol. Oct 15, 2026; 18(10): 122497
Published online Oct 15, 2026. doi: 10.4251/wjgo.122497

Table 6 Comparison of first-line chemotherapy efficacy between the two groups in subgroups with different driver gene statuses, n (%)

Group	n	RAS-mutantion		n	BRAF V600E mutation		n	Wild-type
Group	n	ORR	DCR	n	ORR	DCR	n	ORR	DCR
Normal flora group	22	12 (54.55)	19 (86.36)	3	1 (33.33)	2 (66.67)	23	15 (65.22)	21 (91.30)
Abnormal flora group	24	10 (29.41)	21 (61.76)	7	0 (0.00)	2 (28.57)	35	12 (34.29)	24 (68.57)
χ² value	-	3.538	3.960	-	-	-	-	5.337	4.125
P value	-	0.060	0.047	-	0.300	0.500	-	0.021	0.042

ORR: Objective response rate; DCR: Disease control rate.

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Citation: Wang Y, Dong YW, Wang Y, Jin YY, Zhou YX, Li Y. Association between gut microbial dysbiosis and clinical prognosis of advanced colorectal cancer. World J Gastrointest Oncol 2026; 18(10): 122497
URL: https://www.wjgnet.com/1948-5204/full/v18/i10/122497.htm
DOI: https://dx.doi.org/10.4251/wjgo.122497

Wang Y, Dong YW, Wang Y, Jin YY, Zhou YX, Li Y. Association between gut microbial dysbiosis and clinical prognosis of advanced colorectal cancer. World J Gastrointest Oncol 2026; 18(10): 122497 [DOI: 10.4251/wjgo.122497]

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