Association between gut microbial dysbiosis and clinical prognosis of advanced colorectal cancer

doi:10.4251/wjgo.122497

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Oct 15, 2026; 18(10): 122497
Published online Oct 15, 2026. doi: 10.4251/wjgo.122497

Table 5 Comparison of first-line systemic chemotherapy efficacy and clinical benefit rates between the two groups, n (%)

Efficacy index	Normal flora group (n = 38)	Abnormal flora group (n = 58)	χ² value	P value
CR	3 (7.89)	2 (3.45)	-	0.631
PR	19 (50.00)	17 (29.31)	-	-
SD	12 (31.58)	20 (34.48)	-	-
PD	4 (10.53)	19 (32.76)	-	-
ORR	22 (57.89)	19 (32.76)	5.984	0.014
DCR	34 (89.47)	39 (67.24)	5.872	0.015

CR: Complete response; PR: Partial response; SD: Stable disease; PD: Progressive disease; ORR: Objective response rate; DCR: Disease control rate.

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Citation: Wang Y, Dong YW, Wang Y, Jin YY, Zhou YX, Li Y. Association between gut microbial dysbiosis and clinical prognosis of advanced colorectal cancer. World J Gastrointest Oncol 2026; 18(10): 122497
URL: https://www.wjgnet.com/1948-5204/full/v18/i10/122497.htm
DOI: https://dx.doi.org/10.4251/wjgo.122497

Wang Y, Dong YW, Wang Y, Jin YY, Zhou YX, Li Y. Association between gut microbial dysbiosis and clinical prognosis of advanced colorectal cancer. World J Gastrointest Oncol 2026; 18(10): 122497 [DOI: 10.4251/wjgo.122497]

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