Association between gut microbial dysbiosis and clinical prognosis of advanced colorectal cancer

doi:10.4251/wjgo.122497

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World Journal of Gastrointestinal Oncology

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1948-5204

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Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Oct 15, 2026; 18(10): 122497
Published online Oct 15, 2026. doi: 10.4251/wjgo.122497

Table 4 Multivariate Cox regression analysis of factors influencing overall survival in patients with advanced colorectal cancer

Variable	β	SE	HR	95%CI	P value
Age (≥ 65 years = 1)	0.211	0.325	1.235	0.653-2.337	0.524
Elevated preoperative CEA (yes = 1)	0.204	0.318	1.226	0.658-2.284	0.519
Chemotherapy regimen (combined with targeted therapy = 1)	0.187	0.321	1.206	0.642-2.267	0.558
Histological differentiation (poor = 1, well/moderate = 0)	0.686	0.319	1.985	1.062-3.712	0.031
TNM staging (IV = 1, IIIB-IIIC = 0)	0.782	0.316	2.187	1.176-4.068	0.013
Gut microbial dysbiosis (yes = 1, no = 0)	0.839	0.310	2.314	1.258-4.259	0.007
Radical resection (no = 1, yes = 0)	0.810	0.317	2.246	1.203-4.192	0.011

HR: Hazard ratio; CEA: Carcinoembryonic antigen.

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Citation: Wang Y, Dong YW, Wang Y, Jin YY, Zhou YX, Li Y. Association between gut microbial dysbiosis and clinical prognosis of advanced colorectal cancer. World J Gastrointest Oncol 2026; 18(10): 122497
URL: https://www.wjgnet.com/1948-5204/full/v18/i10/122497.htm
DOI: https://dx.doi.org/10.4251/wjgo.122497

Wang Y, Dong YW, Wang Y, Jin YY, Zhou YX, Li Y. Association between gut microbial dysbiosis and clinical prognosis of advanced colorectal cancer. World J Gastrointest Oncol 2026; 18(10): 122497 [DOI: 10.4251/wjgo.122497]

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