Prognostic significance of Fusobacterium nucleatum in colorectal cancer using reconstructed survival data

Table 2 Survival outcomes based on Fusobacterium nucleatum expression in colorectal cancer

Outcome	Studies, n	Patients (low vs high), n	HR	95%CI	P value	RMST low (95%CI)	RMST high (95%CI)	RMST difference	RMST P value
Overall survival	8	1091 (682 vs 409)	0.99	0.82–1.20	0.93	92.5 (87.18–96.9)	91.4 (85.81–97.2)	1.0	0.462
Disease-free survival	3	1053 (572 vs 481)	0.45	0.37–0.56	< 0.001	102.4 (99.0–105.9)	80.5 (75.8–85.3)	21.8	0.002
Cancer-specific survival	4	630 (185 vs 445)	0.34	0.26–0.44	< 0.001	83.4 (77.0–90.0)	45.0 (40.4–49.5)	38.4	0.002

Hazard ratios compare the low/negative Fusobacterium nucleatum expression group with the high/positive expression group as the reference. A hazard ratio < 1 indicates a lower event risk in the low/negative expression group. CI: Confidence interval; HR: Hazard ratio; RMST: Restricted mean survival time.