CHMP2A as a potential prognostic biomarker for esophageal squamous cell carcinoma promotes tumor angiogenesis and cancer progression

doi:10.4251/wjgo.121843

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World Journal of Gastrointestinal Oncology

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1948-5204

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Oct 15, 2026; 18(10): 121843
Published online Oct 15, 2026. doi: 10.4251/wjgo.121843

Table 2 Univariate and multivariate Cox regression analysis of overall survival in esophageal squamous cell carcinoma patients

Characteristics	Univariate analysis		Multivariate analysis
Characteristics	HR (95%CI)	P value	HR (95%CI)	P value
Gender	1.909 (0.826-4.410)	0.130
Age (year)	1.266 (0.428-3.743)	0.670
Size (cm)	1.139 (0.478-2.716)	0.769
Pathological grading	1.331 (0.491-3.611)	0.575
Lymph node metastasis	4.428 (1.785-10.982)	0.001	3.416 (0.866-13.483)	0.079
Venous invasion	3.254 (1.384-7.654)	0.007	2.060 (0.816-5.205)	0.126
Nerve infiltration	1.073 (0.396-2.911)	0.889
Differentiation	1.854 (0.777-4.424)	0.164
Smoking	0.640 (0.250-1.636)	0.351
Alcohol use	0.676 (0.229-1.999)	0.479
Family history	1.060 (0.313-3.582)	0.926
CHMP2A expression	2.965 (1.090-8.065)	0.033	0.974 (0.219-4.327)	0.972

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Citation: Ma LL, Hao MF, Chen MX, Lu YJ, Su JT, Tong S, Wang JW, Li X, Wei LY, Wang WW, Duan XX, Wang JS. CHMP2A as a potential prognostic biomarker for esophageal squamous cell carcinoma promotes tumor angiogenesis and cancer progression. World J Gastrointest Oncol 2026; 18(10): 121843
URL: https://www.wjgnet.com/1948-5204/full/v18/i10/121843.htm
DOI: https://dx.doi.org/10.4251/wjgo.121843

Ma LL, Hao MF, Chen MX, Lu YJ, Su JT, Tong S, Wang JW, Li X, Wei LY, Wang WW, Duan XX, Wang JS. CHMP2A as a potential prognostic biomarker for esophageal squamous cell carcinoma promotes tumor angiogenesis and cancer progression. World J Gastrointest Oncol 2026; 18(10): 121843 [DOI: 10.4251/wjgo.121843]

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