PARVA promotes gastric cancer progression through FBXO15-related PI3K/AKT signaling

Figure 5 PARVA was associated with FBXO15 expression and PI3K/AKT signaling in gastric cancer cells. A: Kyoto Encyclopedia of Genes and Genomes enrichment analysis of differentially expressed genes after PARVA knockdown; B: Western blot analysis of PI3K, p-PI3K, AKT, and p-AKT expression after PARVA knockdown or overexpression, with densitometric analysis; C: Heatmap of representative differentially expressed genes; D: Western blot analysis of FBXO15 expression after PARVA knockdown or overexpression, with quantification; E: Rescue experiments showing the involvement of FBXO15 in PARVA-mediated regulation of PI3K/AKT signaling. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001. NS: Not significant; NC: Negative control; OE: Overexpression.