PARVA promotes gastric cancer progression through FBXO15-related PI3K/AKT signaling

Figure 3 PARVA knockdown suppressed the proliferation, migration, and invasion of gastric cancer cells. A: Western blot analysis of PARVA knockdown efficiency in AGS and HGC27 cells, with densitometric analysis; B: Colony formation assays with quantification of colony numbers; C: EdU assays with quantification of EdU-positive cells; D: Transwell migration and invasion assays with quantification; E: Wound-healing assays with quantification of wound closure. When followed by a numeral, the comparison refers to the corresponding control within the indicated subgroup. ^aP < 0.01; ^bP < 0.001; ¹Comparison within the migration subgroup; ²Comparison within the invasion subgroup; ³Comparison within the 0 hours subgroup; ⁴Comparison within the 48 hours subgroup. NS: Not significant; NC: Negative control.