Enterocloster bolteae drives hyperglycemia-associated colorectal cancer cell proliferation via Rac/Rho-MSH6-Elongin C signaling pathway

doi:10.4251/wjgo.119879

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World Journal of Gastrointestinal Oncology

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1948-5204

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Oct 15, 2026; 18(10): 119879
Published online Oct 15, 2026. doi: 10.4251/wjgo.119879

Table 4 Spearman correlation analysis between the diabetes mellitus-colorectal cancer group and the diabetes mellitus group

Variable	r	95%CI	P value
Age	0.06827	-0.4104 to 0.5175	0.7812
Male	0.02548	-0.4454 to 0.4854	0.9175
Smoking	-0.04495	-0.5001 to 0.4297	0.8550
Drinking	0.02548	-0.4454 to 0.4854	0.9175
CRC history	0.02548	-0.4454 to 0.4854	0.9175
Hypertension	-0.2955	-0.6690 to 0.1973	0.2194
C polyps history	-0.1086	-0.5466 to 0.3760	0.6580
Antidiabetic drugs	-0.2676	-0.6520 to 0.2263	0.2681
BMI	-0.2776	-0.6582 to 0.2159	0.2498
FPG	0.08770	-0.3940 to 0.5316	0.7211
TG	-0.6334	-0.8487 to -0.2379	0.0036
TCH	-0.1852	-0.5992 to 0.3069	0.4478
HDL	-0.1179	-0.5532 to 0.3679	0.6307
LDL	-0.1951	-0.6057 to 0.2976	0.4236
Abundance of E. bolteae	0.8563	0.6498-0.9451	< 0.0001

CI: Confidence interval; CRC: Colorectal cancer; BMI: Body mass index; FPG: Fasting plasma glucose; TG: Triglyceride; TCH: Total cholesterol; HDL: High-density lipoprotein cholesterol; LDL: Low-density lipoprotein cholesterol.

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Citation: Lai Y, Xu JH, Chen YJ, Luo H, Lin Y, Yu YF, Chen QK. Enterocloster bolteae drives hyperglycemia-associated colorectal cancer cell proliferation via Rac/Rho-MSH6-Elongin C signaling pathway. World J Gastrointest Oncol 2026; 18(10): 119879
URL: https://www.wjgnet.com/1948-5204/full/v18/i10/119879.htm
DOI: https://dx.doi.org/10.4251/wjgo.119879

Lai Y, Xu JH, Chen YJ, Luo H, Lin Y, Yu YF, Chen QK. Enterocloster bolteae drives hyperglycemia-associated colorectal cancer cell proliferation via Rac/Rho-MSH6-Elongin C signaling pathway. World J Gastrointest Oncol 2026; 18(10): 119879 [DOI: 10.4251/wjgo.119879]

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