Clinicopathologic features of SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma: A case report and review of literature

Figure 4 Immunohistochemical staining intensity of several molecular markers. A: Immunohistochemical profiles of pancreatic ductal adenocarcinoma (PDAC) and pancreatic undifferentiated rhabdoid carcinoma (PURC). CK7 and SMARCB1 were positive in PDAC but negative in PURC, whereas CD10 and vimentin were positive in PURC but absent in PDAC. CK-pan and SMARCA4 were expressed in both PDAC and PURC. Ki-67 labeling was higher in PURC compared to PDAC; B: Fluorescence in situ hybridization analysis showing loss of SMARCB1 in a subset of tumor cells, consistent with rhabdoid carcinoma phenotype. Red probes denote SMARCB1, and green probes denote EWSR1. PDAC: Pancreatic ductal adenocarcinoma; PURC: Pancreatic undifferentiated rhabdoid carcinoma; H&E: Hematoxylin and eosin.