Tumor microenvironment-driven microRNA dysregulation: Key interactions in colorectal cancer progression

Table 5 Mesenchymal stem cell-derived exosome-based strategies for microRNA delivery in colorectal cancer[36,159,187-192]

Exo-miR	Cell delivery	Study model	Mechanism	Ref.
Exo-miR30a; miR222	hCC-MSC	In vitro and in vivo	Growth (increase), migration and metastasis (inhibit MIA3)	Du et al[187]
Exo-miR4461	hBM-MSC	In vitro	The proliferation, migration and invasion by down-regulating COPB2 (decrease)	Chen et al[159]
Exo-miR22-3p	hBM-MSC	In vitro	Proliferation and invasion (RAP2B/PI3K/AKT pathway) (decrease)	Wang and Lin[188]
Exo-miR-16-5p	hBM-MSC	In vitro and in vivo	Proliferation, invasion and migration (downregulating ITGA2) (decrease)	Xu et al[36]
Exo-miR431-5p	hUC-MSC	In vitro and in vivo	Progression (suppress PRDX1) (decrease)	Qu et al[189]
Exo-anti-miR-146b-5p ASO	hUC-MSC	In vitro and in vivo	Proliferation, migration and EMT (inhibition of Smad signaling) (decrease)	Yu et al[190]
Exo-miR-486-5p	hUC-MSC	In vitro	Glycolysis and cell stemness by targeting NEK2 (decrease)	Cui et al[191]
Exo-miR-431-5p	hUC-MSC	In vitro and in vivo	Cell growth and progression by inhibiting PRDX1 (decrease)	Qu et al[189]
1Exo-miR-199a-3p	AMSCs	In vitro and in vivo	Sensitized to chemotherapeutic agents by targeting mTOR pathway	Lou et al[192]

¹Hepatocellular carcinoma.

miR: MicroRNA; ASO: Antisense oligonucleotides; hCC-MSC: Human cancer cells-mesenchymal stem cell; hBM-MSC: Human bone marrow-mesenchymal stem cell; hUC-MSC: Human umbilical cord- mesenchymal stem cell; AMSC: Adipose tissue-derived mesenchymal stem cell; PI3K: Phosphatidylinositol 3-kinase; AKT: Protein kinase B; EMT: Epithelial-mesenchymal transition; mTOR: Mammalian target of rapamycin.