Muscle mass correlates with rocuronium distribution volume and guides dose optimization in obese colorectal cancer patients

Table 7 Covariate effects on pharmacokinetic parameters

Parameter	Covariate	△OFV	P value	Inclusion order	Impact
V1	SMI	-41.2	< 0.001	1	18% increase in V1 per 1 kg/m2 increase in SMI
V1	Gender	-12.4	< 0.001	2	24% increase in V1 for males vs females
CL	SMM	-38.6	< 0.001	3	52% increase in CL per 5 kg increase in SMM
CL	Serum albumin	-15.8	< 0.001	4	35% increase in CL per 10 g/L increase in albumin
V2	SMI	-28.3	< 0.001	5	22% increase in V2 per 1 kg/m2 increase in SMI

V1: Central volume of distribution; V2: Peripheral volume of distribution; SMI: Skeletal muscle index; CL: Clearance; SMM: Skeletal muscle mass; OFV: Objective Function value.