Muscle mass correlates with rocuronium distribution volume and guides dose optimization in obese colorectal cancer patients

Table 4 Correlation analysis between skeletal muscle index and rocuronium pharmacokinetic parameters

Pharmacokinetic parameter	Correlation coefficient (r)	95%CI	P value	Corrected P value
Cmax	-0.398	-0.551 to -0.223	< 0.001	< 0.005
AUC0-∞	0.412	0.236-0.568	< 0.001	< 0.005
t1/2	0.368	0.189-0.528	< 0.001	< 0.005
MRT	0.384	0.207-0.542	< 0.001	< 0.005
CL/TBW	-0.486	-0.623 to -0.326	< 0.001	< 0.005
CL/SMM	-0.502	-0.636 to -0.344	< 0.001	< 0.005
Vss/TBW	0.645	0.515-0.748	< 0.001	< 0.005
Vss/IBW	0.692	0.576-0.782	< 0.001	< 0.005
Vss/SMM	0.718	0.609-0.804	< 0.001	< 0.005
Vss/ABW	0.704	0.592-0.791	< 0.001	< 0.005

SMI: Skeletal muscle index; CI: Confidence interval; Cmax: Maximum concentration; AUC_0-∞: Area under the curve from zero to infinity; t₁/₂: Half-life; MRT: Mean residence time; CL: Clearance; TBW: Total body weight; SMM: Skeletal muscle mass; Vss: Volume of distribution at steady state; IBW: Ideal body weight; ABW: Adjusted body weight.