Muscle mass correlates with rocuronium distribution volume and guides dose optimization in obese colorectal cancer patients

Table 3 Rocuronium non-compartmental model pharmacokinetic parameters

Parameter	Total (n = 100)	Sarcopenia group (n = 35)	Non-sarcopenia group (n = 65)	t-test	P value
Cmax (ng/mL)	3198.4 ± 642.7	3542.8 ± 718.2	2986.3 ± 551.4	4.126	< 0.001
Tmax (min)	4.9 ± 1.1	4.7 ± 1.0	5.0 ± 1.2	-1.243	0.217
AUC0-∞ (ng·h/mL)	4674.2 ± 1394.8	3986.4 ± 1186.3	5089.7 ± 1412.6	-3.847	< 0.001
t1/2 (h)	1.38 ± 0.36	1.24 ± 0.29	1.46 ± 0.38	-2.986	0.004
MRT (h)	1.84 ± 0.48	1.68 ± 0.42	1.93 ± 0.51	-2.417	0.018
Clearance (corrected by different weights)
CL/TBW (mL/min/kg)	3.92 ± 1.08	4.48 ± 1.21	3.61 ± 0.94	3.842	< 0.001
CL/ABW (mL/min/kg)	4.86 ± 1.34	5.41 ± 1.46	4.56 ± 1.25	2.892	0.005
CL/IBW (mL/min/kg)	5.71 ± 1.52	6.28 ± 1.68	5.42 ± 1.42	2.641	0.010
CL/SMM (mL/min/kg)	11.84 ± 3.26	14.68 ± 3.84	10.34 ± 2.48	6.124	< 0.001
Steady-state distribution volume (corrected by different weights)
Vss/TBW (L/kg)	0.372 ± 0.092	0.326 ± 0.078	0.398 ± 0.094	-3.842	< 0.001
Vss/ABW (L/kg)	0.488 ± 0.126	0.434 ± 0.108	0.518 ± 0.132	-3.164	0.002
Vss/IBW (L/kg)	0.542 ± 0.141	0.482 ± 0.118	0.576 ± 0.146	-3.267	0.002
Vss/SMM (L/kg)	1.184 ± 0.325	1.086 ± 0.286	1.234 ± 0.342	-2.184	0.032

Cmax: Maximum concentration; Tmax: Time to maximum concentration; AUC_0-∞: Area under the curve from zero to infinity; t₁/₂: Half-life; MRT: Mean residence time; CL: Clearance; TBW: Total body weight; ABW: Adjusted body weight; IBW: Ideal Body weight; SMM: Skeletal muscle mass; Vss: Volume of distribution at steady state.