Muscle mass correlates with rocuronium distribution volume and guides dose optimization in obese colorectal cancer patients

Table 1 Comparison of baseline characteristics of study subjects

Characteristics	Total (n = 100)	Sarcopenia group (n = 35)	Non-sarcopenia group (n = 65)	Test statistic	P value
Age (years)	57.8 ± 11.2	64.1 ± 9.8	54.2 ± 10.9	t = 4.389	< 0.001
Sex, n (%)				χ2 = 8.142	0.004
Male	62 (62.0)	16 (45.7)	46 (70.8)
Female	38 (38.0)	19 (54.3)	19 (29.2)
Height (cm)	167.2 ± 8.7	165.4 ± 9.1	168.3 ± 8.4	t = -1.587	0.116
Weight-related indicators
TBW (kg)	88.4 ± 14.8	85.8 ± 13.2	89.8 ± 15.6	t = -1.254	0.213
BMI (kg/m²)	33.9 ± 4.0	34.8 ± 4.3	33.4 ± 3.8	t = 1.658	0.101
IBW (kg)	61.5 ± 8.2	59.8 ± 8.6	62.5 ± 7.9	t = -1.538	0.127
LBW (kg)	58.6 ± 9.1	54.2 ± 8.3	61.1 ± 8.9	t = -3.741	< 0.001
ABW (kg)	72.3 ± 9.8	71.2 ± 9.4	72.9 ± 10.0	t = -0.814	0.418
Muscle mass indicators
SMM (kg)	25.8 ± 6.4	18.2 ± 3.8	29.6 ± 5.2	t = -12.426	< 0.001
SMI (kg/m2)	7.2 ± 1.6	6.2 ± 0.8	8.4 ± 1.2	t = -10.874	< 0.001
Body fat percentage (%)	38.4 ± 6.8	42.6 ± 7.2	36.1 ± 5.9	t = 4.521	< 0.001
Laboratory indicators
Serum albumin (g/L)	37.4 ± 4.2	34.6 ± 3.7	39.1 ± 3.9	t = -5.642	< 0.001
Serum creatinine (μmol/L)	77.8 ± 18.2	79.4 ± 19.1	76.9 ± 17.8	t = 0.648	0.519
Total bilirubin (μmol/L)	15.6 ± 6.0	16.8 ± 6.4	15.0 ± 5.7	t = 1.426	0.157
Anesthesia-related indicators
ASA classification, n (%)				Z = -2.8471	0.004
Class I	18 (18.0)	3 (8.6)	15 (23.1)
Class II	68 (68.0)	22 (62.9)	46 (70.8)
Class III	14 (14.0)	10 (28.6)	4 (6.2)
Surgical time (h)	3.7 ± 1.1	4.1 ± 1.3	3.5 ± 1.0	t = 2.584	0.011
Intraoperative blood loss (mL)	182.6 ± 76.4	195.8 ± 81.2	175.2 ± 73.6	t = 1.268	0.208

¹Kruskal-Wallis rank sum test used.

TBW: Total body weight; BMI: Body mass index; IBW: Ideal body weight; LBW: Lean body weight; ABW: Adjusted body weight; SMM: Skeletal muscle mass; SMI: Skeletal muscle index; ASA: American Society of Anesthesiologists.