Serum gastrin and Helicobacter pylori infection correlate with tumor aggressiveness and prognosis in gastric cancer

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Sep 15, 2025; 17(9): 110981
Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.110981

Table 4 Logistic regression for gastrin positivity

Predictor	Coefficient (β)	P value	95%CI (lower, upper)	Interpretation
PPI use (yes)	1.567	0.037	(0.095, 3.039)	PPI use significantly increases odds of high gastrin
Helicobacter pylori (positive)	–0.401	0.39	(-1.317, 0.514)	Not statistically significant
Tumor location (body)	0.291	0.562	(-0.694, 1.276)	Not significant
Tumor location (esophagogastric junction)	0.286	0.569	(-0.697, 1.268)	Not significant
TNM stage (III-IV)	–0.143	0.738	(-0.983, 0.696)	Not significant

TNM: Tumor-nodes-metastasis; CI: Confidence interval; PPI: Proton pump inhibitor.

Citation: Huang JW, Lin C, Lu CJ, Wang HS, Zou DD. Serum gastrin and Helicobacter pylori infection correlate with tumor aggressiveness and prognosis in gastric cancer. World J Gastrointest Oncol 2025; 17(9): 110981
URL: https://www.wjgnet.com/1948-5204/full/v17/i9/110981.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i9.110981

Huang JW, Lin C, Lu CJ, Wang HS, Zou DD. Serum gastrin and Helicobacter pylori infection correlate with tumor aggressiveness and prognosis in gastric cancer. World J Gastrointest Oncol 2025; 17(9): 110981 [PMID: 40977652 DOI: 10.4251/wjgo.v17.i9.110981]

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