Transcription factor 3 enhances hepatocellular carcinoma metastasis by upregulating matrix metalloproteinase-11

Figure 4 Matrix metalloproteinase-11 is involved in transcription factor 3 associated hepatocellular carcinoma migration as well as metastasis. A: Western blotting for matrix metalloproteinase-11 Levels in cells; B and C: Transwell assays for cells (magnification: × 10); D and E: Overall survival outcomes for mice in every group; F: Demonstrative hematoxylin and eosin stained lung tissue images. Scale bars: 100 μm (high magnification) and 1 mm (low magnification); G: Counts of lung metastatic nodules in several groups. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. HCC: Hepatocellular carcinoma; MMP11: Matrix metalloproteinase-11; Sh: Short hairpin; TCF3: Transcription factor 3.