Transcription factor 3 enhances hepatocellular carcinoma metastasis by upregulating matrix metalloproteinase-11

Figure 2 Transcription factor 3 promotes hepatocellular carcinoma cell invasion as well as metastasis. A: Western blotting to verify transcription factor 3 (TCF3) overexpression in Hep3B and TCF3 knockdown in HCCLM3 cells; B: Migration as well as invasions of hepatocellular carcinoma cells as determined by Transwell assays (magnification: × 10); C: Overall survival outcomes for mice in each group; D: Demonstrative hematoxylin and eosin staining images for lung metastases in mice with transfected cells. Scale bars: 100 μm (high magnification) and 1 mm (low magnification); E: Counts of lung metastatic nodules in groups. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001. HCC: Hepatocellular carcinoma; Sh: Short hairpin; TCF3: Transcription factor 3.