Transcription factor 3 enhances hepatocellular carcinoma metastasis by upregulating matrix metalloproteinase-11

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastrointest Oncol. Sep 15, 2025; 17(9): 110527
Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.110527

Table 1 Correlation between transcription factor 3 expression and Clinicopathological factors of patients with hepatocellular carcinoma

Variables	TCF3 expression of low (n = 41)	TCF3 expression of high (n = 35)	P value
Age (years)
< 60	19	15	0.761
≥ 60	22	20	0.761
Gender
Male	23	20	0.927
Female	18	15	0.927
Hepatitis B virus infection
Negative	12	6	0.215
Positive	29	29	0.215
Cirrhosis
Absent	13	10	0.767
Present	28	25	0.767
Alpha-fetoprotein
Elevatory	26	26	0.310
Normal	15	9	0.310
Differentiation
Well	16	8	0.0326
Moderate	20	14
Poor	5	13
Tumor size
≤ 5 cm	25	16	0.183
> 5 cm	16	19	0.183
Number of tumors
Single	33	22	0.087
Multiple	8	13	0.087
Lymph node metastasis
Absent	29	11
Present	12	24	0.001
Microvascular invasion
Absent	31	18	0.028
Present	10	17	0.028
American Joint Committee on Cancer stage
I	15	3	0.0107
II	6	11
III	20	21

TCF3: Transcription factor 3.

Citation: Tian HP, Wu TH, Zhang GJ, Li SJ. Transcription factor 3 enhances hepatocellular carcinoma metastasis by upregulating matrix metalloproteinase-11. World J Gastrointest Oncol 2025; 17(9): 110527
URL: https://www.wjgnet.com/1948-5204/full/v17/i9/110527.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i9.110527

Tian HP, Wu TH, Zhang GJ, Li SJ. Transcription factor 3 enhances hepatocellular carcinoma metastasis by upregulating matrix metalloproteinase-11. World J Gastrointest Oncol 2025; 17(9): 110527 [PMID: 40977645 DOI: 10.4251/wjgo.v17.i9.110527]

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