Prognostic factors and efficacy of postoperative chemotherapy in patients with gastric cancer with positive peritoneal cytology after gastrectomy

Table 4 Univariate and multivariate analysis of overall survival in patients with peritoneal lavage cytology-positive who underwent postoperative chemotherapy

Variables	n	Univariate analysis		Multivariate analysis
		HR (95%CI)	P value	HR (95%CI)	P value
Age (years)
≤ 75	29	Reference
> 75	13	1.39 (0.58-3.33)	0.460
Gender
Male	34	Reference
Female	8	1.55 (0.57-4.21)	0.395
Performance status (ECOG)
0, 1	41	Reference
2	1	1.82 (0.24-13.69)	0.562
Pre-chemotherapy BMI (kg/m2)
≥ 25	2	Reference
< 25	37	1.21 (0.16-9.04)	0.854
Pre-chemotherapy CEA
≤ ULN	36	Reference
> ULN	6	1.46 (0.49-4.30)	0.498
Pre-chemotherapy CA19-9
≤ ULN	38	Reference
> ULN	3	1.53 (0.36-6.60)	0.566
Surgery
DG, PG	25	Reference
TG	17	1.21 (0.52-2.82)	0.667
Lymph node dissection
≥ D2	35	Reference
< D2	7	1.09(0.37-3.22)	0.883
Postoperative complication
No	34	Reference
Yes	8	1.18 (0.43-3.21)	0.746
Macroscopic type
Non-type 4	14	Reference		Reference
Type 4	28	2.17 (0.92-5.09)	0.076	5.00 (1.76-14.25)	0.003
Histology
Intestinal	15	Reference
Diffuse	27	1.78 (0.72-4.38)	0.210
pT
T3	9	Reference
T4	33	1.86 (0.55-6.33)	0.318
pN
N0-2	19	Reference
N3	23	0.98 (0.42-2.27)	0.964
HER2 status
Positive	10	Reference
Negative	24	2.09 (0.69-6.39)	0.194
Postoperative CTx
New combination chemotherapy	17	Reference		Reference
Conventional chemotherapy	25	5.34 (1.77-16.14)	0.003	9.53 (2.54-35.79)	< 0.001
Duration of postoperative CTx
≥ 1 year	16	Reference		Reference
< 1 year	26	12.75 (2.98-55.55)	< 0.001	18.98 (3.68-97.93)	< 0.001
Ccr (mL/minute)
≥ 60	27	Reference
< 60	15	1.08 (0.45-2.61)	0.862
Grade III adverse event1
No	22	Reference
Yes	20	0.64 (0.27-1.55)	0.326

¹Common Terminology Criteria for Adverse Event v5.0.

HR: Hazard ratio; CI: Confidence interval; ECOG: Eastern Cooperative Oncology Group; BMI: Body mass index; CEA: Carcinoembryonic antigen; ULN: Upper limit of normal; CA19-9: Carbohydrate antigen 19-9; DG: Distal gastrectomy; PG: Proximal gastrectomy; TG: Total gastrectomy; HER2: Human epidermal growth factor receptor 2; CTx: Chemotherapy; Ccr: Creatineine clearance.