Prognostic factors and efficacy of postoperative chemotherapy in patients with gastric cancer with positive peritoneal cytology after gastrectomy

Table 3 Characteristics of patients with peritoneal lavage cytology-positive who undergo gastrectomy followed by postoperative chemotherapy, n (%)

	Conventional chemotherapy1 (n = 25)	New combination chemotherapy2 (n = 17)	P value
Age (years)	72 (42-87)	66.2 (45-76)	0.073
Gender			0.589
Male	20 (80)	14 (82)
Female	5 (20)	3 (18)
Performance status (ECOG)			0.595
0, 1	24 (96)	17 (100)
2	1 (4)	0 (0)
Preoperative BMI (kg/m2)	21.1 (17.5-27.7)	21.7 (17.3-27.5)	0.531
CEA			0.437
≤ ULN	20 (83)	13 (76)
> ULN	4 (7)	4 (24)
CA19-9			0.565
≤ ULN	19 (79)	13 (76)
> ULN	5 (21)	4 (24)
Surgery			0.175
DG, PG	17 (68)	8 (47)
TG	8 (32)	9 (53)
Lymph node dissection			0.397
≥ D2	20 (80)	15 (88)
< D2	5 (20)	2 (12)
Postoperative complication			0.589
No	20 (80)	14 (82)
Yes	5 (20)	3 (18)
Macroscopic type			0.173
Non-type 4	9 (36)	3 (18)
Type 4	16 (64)	14 (82)
Histology			0.542
Intestinal	8 (32)	7 (41)
Diffuse	17 (68)	10 (59)
pT			0.463
T3	6 (24)	3 (18)
T4	19 (76)	14 (82)
pN			0.845
N0-2	11 (44)	8 (47)
N3	14 (56)	9 (53)
HER2 status			0.346
Positive	16	8
Negative	6	4
Unknown	3	5
BW decrease rate3			0.465
< 10%	18 (81)	15 (88)
≥ 10%	4 (19)	2 (12)
Pre-chemotherapy BMI (kg/m2)	19.9 (15.1-26.3)	20.7 (16.0-25.5)	0.377
Ccr (mL/minute)			0.174
< 60	14 (56)	13 (82)
≥ 60	11 (44)	4 (18)
Pre-chemotherapy CEA			0.534
≤ ULN	21 (84)	15 (88)
> ULN	4 (16)	2 (12)
Pre-chemotherapy CA19-9			0.630
≤ ULN	22 (92)	16 (94)
> ULN	2 (8)	1 (6)

¹Conventional chemotherapy includes S1 monotherapy or combination therapy with fluoropyrimidine + cisplatin.

²Novel chemotherapy include fluoropyrimidine + oxaliplatin or fluoropyrimidine + docetaxel.

³BW decrease rate represents the rate of weight loss from the time of surgery to the initiation of chemotherapy.

ECOG: Eastern Cooperative Oncology Group; BMI: Body mass index; CEA: Carcinoembryonic antigen; ULN: Upper limit of normal; CA19-9: Carbohydrate antigen 19-9; DG: Distal gastrectomy; PG: Proximal gastrectomy; TG: Total gastrectomy; HER2: Human epidermal growth factor receptor 2; BW: Body weight; Ccr: Creatineine clearance.