Prognostic factors and efficacy of postoperative chemotherapy in patients with gastric cancer with positive peritoneal cytology after gastrectomy

Table 2 Univariate and multivariate analysis of overall survival in patients with peritoneal lavage cytology-positive who underwent gastrectomy

Variables	n	Univariate analysis		Multivariate analysis
		HR (95%CI)	P value	HR (95%CI)	P value
Age (years)
≤ 75	41	Reference		Reference
> 75	41	2.20 (1.25-3.87)	0.006	1.81 (0.98-3.34)	0.057
Gender
Male	56	Reference		Reference
Female	26	1.79 (1.01-3.21)	0.048	1.45 (0.79-2.69)	0.233
Performance status (ECOG)
0, 1	76	Reference
2	6	1.03 (0.32-3.33)	0.955
BMI (kg/m2)
< 25	73	Reference
≥ 25	8	1.06 (0.42-2.67)	0.900
Preoperative CEA
≤ ULN	60	Reference
> ULN	21	1.50 (0.81-2.80)	0.201
Preoperative CA19-9
≤ ULN	55	Reference
> ULN	25	0.81 (0.42-1.56)	0.527
Surgery
DG, PG	45	Reference
TG	37	1.21 (0.70-2.10)	0.504
Lymph node dissection
≥ D2	61	Reference
< D2	21	1.36 (0.71-2.62)	0.354
Postoperative complication
No	60	Reference
Yes	22	1.47 (0.82-2.63)	0.200
Macroscopic type
Non-type 4	60	Reference
Type 4	22	1.63 (0.90-2.95)	0.107
Histology
Intestinal	31	Reference		Reference
Diffuse	51	1.89 (1.05-3.39)	0.034	2.65 (1.43-4.92)	0.002
pT
T3	16	Reference
T4	66	1.14 (0.53-2.42)	0.743
pN
N0-2	36	Reference
N3	46	1.08 (0.62-1.88)	0.785
Postoperative CTx
Yes	42	Reference		Reference
No	40	3.24 (1.82-5.78)	0.001	3.26 (1.75-6.08)	0.001

HR: Hazard ratio; CI: Confidence interval; ECOG: Eastern Cooperative Oncology Group; BMI: Body mass index; CEA: Carcinoembryonic antigen; ULN: Upper limit of normal; CA19-9: Carbohydrate antigen 19-9; DG: Distal gastrectomy; PG: Proximal gastrectomy; TG: Total gastrectomy; CTx: Chemotherapy.