Immune checkpoint molecules signal regulatory protein alpha in the development of hepatocellular carcinoma

doi:10.4251/wjgo.v17.i9.109824

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Sep 15, 2025; 17(9): 109824
Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.109824

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Figure 3 The mechanism of signal regulatory protein alpha. A: The signal regulatory protein alpha (SIRPα)/interleukin-6 axis may promote lung cancer development; B: Upregulation of SIRPα promotes osteosarcoma metastasis through the "SP1 stable loop" and SLC 7A3 mediated arginine uptake; C: SIRPα (-/-) macrophages promote T cell recruitment into tumors through Syk/Btk dependent Ccl8 secretion.

Citation: Zhang X, Chen DB, Zhang R, Chen P, She SP, Yang Y, Ren LY, Chen HS. Immune checkpoint molecules signal regulatory protein alpha in the development of hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(9): 109824
URL: https://www.wjgnet.com/1948-5204/full/v17/i9/109824.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i9.109824

Zhang X, Chen DB, Zhang R, Chen P, She SP, Yang Y, Ren LY, Chen HS. Immune checkpoint molecules signal regulatory protein alpha in the development of hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(9): 109824 [PMID: 40977647 DOI: 10.4251/wjgo.v17.i9.109824]

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