Untargeted metabolomics analysis of metabolite changes in gastric cancer patients from plateau regions

Table 5 Pathway analysis of differential fecal metabolites between the gastric cancer and control groups

Pathway name	Total	Hits	Raw P value	Impact
Purine metabolism	92	4	0.0072593	0.01303
Cysteine and methionine metabolism	56	3	0.011789	0.08586
Galactose metabolism	41	2	0.048471	0.06586
Lysine degradation	47	2	0.061937	0.07943
Glycine, serine, and threonine metabolism	48	2	0.064295	0.22194
Biotin metabolism	11	1	0.092074	0.19512
Pyrimidine metabolism	60	2	0.094814	0.02789
Arginine and proline metabolism	77	2	0.14362	0.01997
Histidine metabolism	44	1	0.32231	0.01609
Primary bile acid biosynthesis	47	1	0.34023	0.00822
Starch and sucrose metabolism	50	1	0.35769	0.00944
Tyrosine metabolism	76	1	0.49167	0.01424

"Total" represents the total number of metabolites in the pathway; "Hits" refers to the number of differential metabolites involved in the pathway; "Raw P value" is the P value from pathway analysis; "Impact" is the impact value from topology analysis.