Rapamycin suppresses small bowel adenocarcinoma HUTU 80 cells proliferation by inhibiting hypoxia-inducible factor-1α mediated metabolic reprogramming

Figure 7 Effects of rapamycin on HUTU 80 cells proliferation in vivo. A: Tumor anatomies showing the subcutaneous xenograft model with different treatments of HUTU 80 cells as well as the tumor anatomy of the euthanized mice (n = 6 mice per group); B: Weight of mouse tumors; C: Tumor volume change curves of mice; the tumor volume was calculated as [length (mm) × width (mm) × width (mm)]/2; D: Tumor weight change curves of mice. Data are presented as the mean ± SD (n = 6); E: Hematoxylin-eosin staining of the internal organs of nude mice after different treatments. Data are presented as the mean ± SD (n = 3). ^aP < 0.05. ^bP < 0.01. ^cP < 0.001. RAPA: Rapamycin.