Rapamycin suppresses small bowel adenocarcinoma HUTU 80 cells proliferation by inhibiting hypoxia-inducible factor-1α mediated metabolic reprogramming

Figure 5 Metabolome results of rapamycin treatment with HUTU 80 cells and combined omics analysis. A: Volcano plot demonstrated the quantity of different metabolites; B: Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed the top 10 metabolomic pathways related to antitumor effects; C: Heatmap displayed differential metabolites; D: Venn diagram revealed the number of KEGG pathways commonly annotated by different molecules in the transcriptome and metabolome; E: Bar graph displaying the top 10 KEGG pathways with the total number of differential molecules related to anti-cancer properties selected from two groups (number of different genes and number of different metabolites). VIP: Variable importance in projection; HIF-1α: Hypoxia-inducible factor-1α.