Methionyl-tRNA synthetase 1 participates in hepatocellular carcinoma and its regulated gene profile possesses potent prognostic ability

Figure 1 MARS1 is a key gene associated with hepatocellular carcinoma. A: Flow chart illustrating the study design and workflow; B: Visualization of differentially expressed genes (DEGs) in hepatocellular carcinoma (HCC) compared to adjacent normal tissue; C: Mutation analysis and Kaplan-Meier survival curves based on DEGs identified in panel (B); D: Differential expression of MARS1 in HCC and normal tissue; E and F: Western blot (E) and Immunohistochemistry (F) showing MARS1 expression in HCC and normal liver tissues. Student’s t-test was used to compare differences between two groups. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001. TCGA: The Cancer Genome Atlas; HCC: Hepatocellular carcinoma; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes.