Ginsenoside F4 inhibits colorectal cancer progression by boosting dendritic cell maturation and remodeling the tumor microenvironment

Figure 5 Effects of F4 on the tumor growth of CT26-bearing mice. A: Inhibition of F4 on the tumor size and tumor/body weight ratio in CT26-bearing mice; B: The landscapes of peripheral immune cells detected by using 15-color spectral flow cytometry; C: The levels of interferon-γ, interleukin-2, and interleukin-12 p70 in the serum detected by enzyme-linked immunosorbent assay. All data were shown as mean ± SD (n = 5). ^aP < 0.05. P vs model group. Ctrl: Control; CAP: Capecitabine; L: Low; M: Middle; H: High; CD: Cluster of differentiation; eCD: Effective cluster of differentiation; mCD: Memory cluster of differentiation; nCD: Native cluster of differentiation; FSC-H: Forward scatter height; FSC-A: Forward scatter area; APC: Allophycocyanin; BV: Brilliant violet; UV: Ultraviolet; PE: Phycoerythrin; SSC-A: Side scatter area; PE-A: Phycoerythrin area; DC: Dendritic cells; IFN: Interferon; IL: Interleukin.