Ginsenoside F4 inhibits colorectal cancer progression by boosting dendritic cell maturation and remodeling the tumor microenvironment

Figure 2 Dendritic cells cultured with F4 enhanced the cytotoxicity of cluster of differentiation 8 + T cells against CT26 cells. A: Effects of F4-stimulated dendritic cells (DCs) on the proliferation of T cells; B: Cytotoxicity of tumor-specific cytotoxic T lymphocyte (CTL) responses against CT26 cells by F4-treated DCs; C and D: DC-stimulated cluster of differentiation 8 + T cells induced the apoptosis of CT26 cells; E: The relative levels of Bcl-2, Bax and caspase-3 message RNA in CTL-stimulated CT26 cells. All data were shown as mean ± SD (n = 5). ^aP < 0.05. ¹P vs control group. ²P vs lipopolysaccharides group. Ctrl: Control; LPS: Lipopolysaccharides; PI: Propidium iodide.