Ginsenoside F4 inhibits colorectal cancer progression by boosting dendritic cell maturation and remodeling the tumor microenvironment

Figure 1 F4 promoted the maturation of bone marrow-derived dendritic cells in vitro. A: Cytotoxicity of F4 on the proliferation of mouse colon CT26 cells; B: The purity (representative data) of bone marrow-derived dendritic cells (BMDCs) identified by flow cytometry; C: Cytotoxicity of F4 on the proliferation of BMDCs; D: Effects of F4 on the morphological change of BMDCs; E: Effects of F4 on the expressions of DC surface biomarkers cluster of differentiation (CD) 83 and CD86; F: Effects of F4 on the release of cytokines in the culture mediums. All data were shown as mean ± SD (n = 5). ^aP < 0.05. ¹P vs control group. ²P vs lipopolysaccharides group. Ctrl: Control; 5-FU: 5-fluorouracil; CD: Cluster of differentiation; SSC-H: Side scatter high; BMDCs: Bone marrow-derived dendritic cells; LPS: Lipopolysaccharides; IL: Interleukin.